Inform choices about trial design, data collection, and analysis E.g., superiority vs. non-inferiority? How to handle events that might occur after randomization (use of rescue drug, etc.)?
Principles of Good Clinical Trial Design - PMC
In this article, we present some general principles of good clinical trial design, which are often used as the basis to evaluate the quality of the evidence presented in manuscripts reporting …
Nov 8, 2023 · Outline the differences between classical and novel clinical trial designs and explain how they relate to established clinical trials. Explain the impact that innovative clinical trial …
How to Design and Run an Effective Clinical Trial
Clinical trials are critical to the advancement of healthcare, but designing and running them effectively are skills that are rarely taught in medical or graduate school.
Clinical trial design - Latest research and news | Nature
Dec 15, 2025 · Clinical trial design is a key aspect of the successful conduct of clinical trials.
Clinical Trials: Design, Strategy, and Analysis - Stanford Online
Compare the advantages and disadvantages of different trial types and review three frameworks for clinical trials. Learn how to organize a research question using PICOT framework, be able …
How to Design a Clinical Study: Principles & Protocol Development
Participants will learn the fundamentals of clinical trial design, including instructions on how to design a protocol, information on IRB and regulatory topics, and trial implementation.
Clinical Trial Design - an overview | ScienceDirect Topics
Clinical trial design refers to the structured approach used in clinical trials to evaluate the effects of interventions on health-related outcomes, incorporating elements such as randomization, …
In recent years there has been significant focus on using innovative and more complex clinical trials with the aim of increasing the effectiveness and efficiency of clinical trials to provide high …
Clinical Trial Designs | CLINICAL TRIAL RISK TOOL
Clinical trial designs vary considerably, impacting study execution, patient recruitment, endpoints, and treatment delivery. Here’s a brief summary of some common designs: These are the initial …
Effective clinical trial design: a guide | Within3
Dec 9, 2025 · With a shift to more virtual clinical trials, what lessons can we apply to clinical study design? And what novel technologies can bolster their efficiency and clarity of their results? …
(PDF) Clinical trial designs: a simplified overview - ResearchGate
Jul 11, 2023 · In this article, we presented an overview of clinical trial designs emphasizing adaptive designs in a simplified way for field-based clinical research professionals.
Dec 4, 2024 · A well-designed clinical trial not only strengthens the scientific validity but also facilitates the accurate interpretation of results and contributes to medical knowledge and …
Overview of clinical study designs - PMC
A clinical trial is a prospective study of the effects of interventions or manipulations of interest. Since this type of study can provide the most convincing demonstration of evidence of …
Best Practices for Designing Effective Clinical Drug Trials
Sep 11, 2024 · Designing effective clinical drug trials requires a strategic approach. Key elements include setting clear, SMART objectives, conducting a thorough literature review, and …
Adaptive Trial Design Is Changing Oncology And Hematology Clinical Trials
Dec 16, 2025 · Pfizer Global Development Lead, Clinical Development Oncology & Hematology, Shreya Badhrinarayanan, MD, explains how adaptive trials, enriched by AI …
Advancing CAR T-Cell Therapy: Evidence-Based Trial Design for …
Dec 8, 2025 · This Viewpoint discusses the recent decision by the US Food and Drug Administration to eliminate Risk Evaluation and Mitigation Strategies requirements for chimeric …
Principles of Good Clinical Trial Design
Feb 14, 2020 · In this article, we present some general principles of good clinical trial design, which are often used as the basis to evaluate the quality of the evidence presented in …
An introduction to clinical trial design - ScienceDirect
Nov 1, 2019 · A good working knowledge of clinical trial design is essential to expertly interpret and determine the validity and generalizability of the results. This manuscript will give a brief …
Clinical trial designs: a simplified overview
Jul 11, 2023 · In this article, we presented an overview of clinical trial designs emphasizing adaptive designs in a simplified way for field-based clinical research professionals.
ADCs in Oncology Clinical Research: Innovation in Precision and Trial …
Dec 17, 2025 · Evolving Trial Design, Regulatory Dialogue and Clinical Rigor Dr. Sullivan expects oncology trial design to continue evolving in step with scientific innovation. Adaptive designs, …
Randomized controlled trial - Wikipedia
The term randomized controlled clinical trial is an alternative term used in clinical research; [10] however, RCTs are also employed in other research areas, including many of the social …
Principles of Good Clinical Trial Design - ScienceDirect
Aug 1, 2020 · In this article, we present some general principles of good clinical trial design, which are often used as the basis to evaluate the quality of the evidence presented in manuscripts …
AI Revolutionizes Clinical Trials: From Design Certainty to Peak ...
5 days ago · Leveraging unparalleled clinical trial data—including over 30,000 historical studies, 11 million patients, and 70 billion data points—AI is purpose-built to accelerate trials from the …
May 15, 2020 · In this article, we present some general prin-ciples of good clinical trial design, which are often used as the basis to evaluate the quality of the evidence pre-sented in …