Bacterial ribosomes are essential for protein synthesis, yet they can become stalled during translation when encountering aberrant mRNAs or premature termination signals. To preserve the efficiency of ...

Using ribosome engineering (RE), researchers from Shinshu University introduced mutations affecting the protein synthesis ...

Ribosomes are tiny molecular machines inside all living cells that build proteins, and ribosome biogenesis is the complex, multi-step process by which they are made. During brain development, neural ...

A previously unknown mechanism that makes it possible for aggressive so-called triple-negative breast cancer to fine-tune its ...

Slower ribosomes stall during translation and collide with faster ones, triggering selective degradation of their small subunits. This “ribosome competition” mechanism ensures that only efficient ...

Maximiliane Wieland, Mikael Holm, Emily J. Rundlet, Martino Morici, Timm O. Koller, Tinashe P. Maviza, Domen Pogorevc, Ilya A. Osterman, Rolf Müller, Scott C ...

Research by UC Santa Cruz molecular biologist Harry Noller and his collaborators has led to the first direct observations of the mechanism for protein synthesis in living cells. Their new findings on ...

A virus relies on the host's translation machinery to replicate itself and become infectious. Translation efficiency ...