The American Society for Reproductive Medicine published a report that concludes preimplantation genetic testing for ...

Polygenic background bidirectionally modifies the penetrance of pathogenic variants in hypertrophic (HCM) and dilated (DCM) ...

The optimism is not unfounded. In specific, well-defined clinical scenarios, polygenic scores are beginning to demonstrate some tangible utility. For cardiovascular disease, MI-GENES, a 10-year follow ...

In this series, ‘Genomics 101’, we go back to basics and explore some of the most important topics in genomics. In this blog, we explain the meaning of dominant and recessive genes, and how they are ...

A mother’s genes may influence a child’s weight more strongly than a father’s genes. This is the conclusion of a major study led by researchers at University College London. The analysis combines deep ...

In Mendelian inheritance patterns, you receive one version of a gene, called an allele, from each parent. These alleles can be dominant or recessive. Non-Mendelian genetics don’t completely follow ...

“What makes the score so powerful is its ability to predict, before the age of five, whether a child is likely to develop obesity in adulthood, well before other risk factors start to shape their ...

Nearly all men with a polygenic risk score in the 90th percentile or above had a 10-year absolute risk for prostate cancer exceeding 3.8%. A polygenic risk score (PRS) identifies more patients with ...

The results of research by scientists at University College London (UCL), Imperial College London, and the MRC Laboratory of Medical Sciences, indicate that a potentially life-changing heart condition ...