To study how a key chemical neuromodulator affects signaling in the brain's cortex, Garrett Neske, PhD, has received a three-year, $300,000 grant from the Whitehall Foundation, a nonprofit ...
A new ‘biomimetic’ model of brain circuits and function at multiple scales produced naturalistic dynamics and learning, and ...
This study presents SynaptoGen, a differentiable extension of connectome models that links gene expression, protein-protein interaction probabilities, synaptic multiplicity, and synaptic weights, and ...
Study Finds on MSN
Scientists watch brain cells talk to each other in real time
Scientists developed two new sensors that can detect brain cell communication in real time, tracking chemical messages ...
Not revised: This Reviewed Preprint includes the authors’ original preprint (without revision), an eLife assessment, and public reviews. This research sheds light on the dynamics of the excitatory and ...
BIN1, a late-onset Alzheimer’s disease (LOAD) genetic risk factor, is involved in many cellular phenomena, including vesicular trafficking and tau production. Now, in the August 26 Cell Reports, ...
Summary: A small genetic sequence called mini-exon B plays a surprisingly crucial role in how neurons form synaptic connections, according to new research. Scientists found that deleting this ...
Deletion of mini-exon B in the synaptic adhesion molecule PTPδ leads to altered neural connectivity from the entorhinal cortex to the dentate gyrus (left panel). In mice lacking mini-exon B, ...
Summary: A research team has uncovered a molecular “switch” that precisely regulates NMDA receptors, key players in brain communication, by blocking excitatory synapse overactivity. The proteins MDGA2 ...
To identify putative miRs involved in homeostatic plasticity, Colameo et al., leveraged a prior multiomics study in which the authors conducted RNA sequencing in cultured hippocampal neurons to ...
Co-written with Jai Liester. Silent synapses represent one of neuroscience's most fascinating discoveries—connections between neurons that lie dormant until activated by specific triggers. These ...
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