Arriving early or late can have big consequences for early-stage cells that gather to form a new kidney, a team of USC researchers discovered. The scientists showed how progenitor cells that form the ...

In videos created by the Hughes Lab to visualize the process, adjacent nephrons form one after the other, as if they were following a beat. “It’s still a hypothesis,” adds Hughes, “but we think that ...

In the lab, it's easier to grow simple balls of cells than complex asymmetrical structures with two distinct ends—like the one million filtering units—nephrons—that make up a human kidney. But new ...

The gene KCTD1 directs production of a protein that functions in the kidney to maintain a normal balance of magnesium and calcium in blood. Loss of KCTD1 impairs the ability of the kidney to properly ...

To Alex Hughes, Assistant Professor in Bioengineering within Penn Engineering and in Cell and Developmental Biology within Penn Medicine, the kidney is a work of art. "I find the development of the ...

Perfectly punctual or fashionably late, it takes all kinds to build a kidney. So it is for stem cells building kidney tissue discovered timing is critical as the precise arrival of progenitor cells ...