A large international study led by researchers at Memorial Sloan Kettering has immediate clinical relevance for risk assessment and treatment of people with myelodysplastic syndrome and acute myeloid ...
TP53 mutations are crucial in cancer development and treatment response, influenced by genetic and environmental factors. In CLL and AML, TP53 serves as a significant prognostic marker, affecting ...
We studied p53 expression by high-throughput reverse phase protein array (RPPA) technology in 511 patients with newly diagnosed AML and 21 patients with newly diagnosed acute promyelocytic leukemia ...
p53 mutants are among the most common protein variants expressed in cancer cells. Classifying TP53 status in human cancer as ‘inactivated’ or ‘loss-of-function’ is misleading. Many mutant p53 variants ...
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The TP53 gene and its role in cancer
What is TP53 and what role does it play in cancer? Medically reviewed by Marla Anderson, MD The TP53 gene helps prevent cancer by repairing DNA or causing cell death when DNA is too damaged. Mutations ...
TP53 is a gene located on chromosome 17 that, when normal, stops cells from growing and dividing. You can inherit a TP53 mutation from your parents or develop one later in life. An inherited TP53 ...
Patients with myelofibrosis (MF) with single-hit mutations had similar outcomes to patients with wild-type TP53. People with myelofibrosis (MF) who undergo hematopoietic stem cell transplantation ...
Abbreviations: SickKids, The Hospital for Sick Children, Toronto, Ontario, Canada; CHLA, Children's Hospital of Los Angeles, CA; CHTN, Collaborative Human Tissue ...
In Brazil, the early detection of genetic alterations in lung cancer through liquid biopsies could be a valuable tool for ...
The TP53 is a gene that instructs the cell to produce tumor protein (p53) ; a vital transcription factor and tumor suppressor. P53 is known as the “guardian of the genome” as it helps in regulating ...
In a recent perspective published in the journal Cell Death and Differentiation, researchers in France, Germany, and Sweden discussed the unique mutational spectrum of the transformation-related ...
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