The patient had a long history of common variable immunodeficiency enteropathy, a condition characterized by diarrhea, malabsorption, and duodenal villous atrophy with intraepithelial lymphocytosis; ...

The Glickman lab, in close collaboration with the Shuman lab, is broadly interested in the pathways and regulation of DNA repair in mycobacteria. Our goals in the DNA repair arena are twofold: 1) to ...

De novo mutations are a cause of sporadic disease, but little is known about the developmental timing of such mutations. We studied concordant and discordant monozygous twins with de novo mutations in ...

Site-directed mutagenesis (SDM) has been an important feature of the research landscape since its introduction in 1995. Continuing improvements to Pfu DNA polymerase have led to enhancements in the ...

Site-directed mutagenesis (SDM) is a commonly used technique for introducing mutations into a gene of interest. Existing techniques for SDM, such as whole plasmid SDM, while effective, are time ...

Scientists are finding new ways to improve the use of the CRISPR enzyme Cas9 and reduce the chances of off-target mutations in laboratory mice, according to new results. The findings will help ...

During photosynthesis, an enzyme called rubisco catalyzes a key reaction—the incorporation of carbon dioxide into organic compounds to create sugars. However, rubisco, which is believed to be the most ...

This comprehensive book covers the underlying scientific principles, state of the art technologies and methodologies of plant mutagenesis. It covers historical development and commonly used ...

Europe’s highest court on Wednesday ruled that a new generation of plants developed through controversial gene-editing techniques should be subject to the same strict EU laws that apply to genetically ...