Glycosylphosphatidylinositol (GPI) anchors are essential glycolipids that secure a variety of proteins to the outer leaflet of the plasma membrane, thereby ensuring correct spatial organisation and ...
Glypicans are a family of glycosylphosphatidylinositol (GPI)-anchored cell surface heparan sulfate proteoglycans (HSPGs). The glypican family, which currently includes glypican, the developmentally ...
Anthony Davies, Ivan Kadurin, Anita Alvarez-Laviada, Leon Douglas, Manuela Nieto-Rostro, Claudia S. Bauer, Wendy S. Pratt, Annette C. Dolphin, William A. Catterall Proceedings of the National Academy ...
Impaired intelligence, movement disorders and developmental delays are typical for a group of rare diseases that belong to GPI anchor deficiencies. Researchers now used genetic engineering methods to ...
Precursor proteins and GPI are synthesized separately in the ER and the protein is attached to the completed GPI anchor and further modified and transported to the plasma membrane. Disclaimer: AAAS ...
This release is available in German. The cause of diseases such as BSE in cattle and Creutzfeld–Jakob disease in humans is a prion protein. This protein attaches to cell membranes by way of an anchor ...
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